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What are the genotypic and phenotypic ratios for a cross between a heterozygous type A mother ($I^A i$) and a homozygous type B father ($I^B I^B$) in the ABO blood group system?

What are the genotypic and phenotypic ratios for a cross between a heterozygous type A mother ($I^A...
Answer

Cross $I^A i \times I^B I^B$: the mother makes gametes $I^A$ and $i$, and the father makes only $I^B$ gametes. Offspring are 50% $I^A I^B$ (type AB) and 50% $I^B i$ (type B). So the genotypic ratio is $1\, I^A I^B: 1\, I^B i$ and the phenotypic ratio is $1\, AB: 1\, B$.

Explanation

What you are crossing in ABO blood types

ABO blood type is controlled by three alleles: $I^A$, $I^B$, and $i$. The alleles $I^A$ and $I^B$ are codominant (both show if together), and $i$ is recessive.

List the parental genotypes and gametes

  • Mother (heterozygous type A): $I^A i$ Gametes: $I^A$ or $i$
  • Father (homozygous type B): $I^B I^B$ Gametes: only $I^B$

Combine gametes to get offspring genotypes

Possible children:

  • $I^A$ (mom) + $I^B$ (dad) $\rightarrow I^A I^B$ (phenotype AB)
  • $i$ (mom) + $I^B$ (dad) $\rightarrow I^B i$ (phenotype B)

Ratios (genotype and phenotype)

Because the mother produces $I^A$ and $i$ gametes equally often, the outcomes are split evenly:

  • Genotypic ratio: $1\, I^A I^B: 1\, I^B i$
  • Phenotypic ratio: $1\, AB: 1\, B$

Quick check

No child can be type A or type O here because the father always contributes an $I^B$ allele.

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Skills You Achive
punnett squares mendelian genetics codominance abO blood types

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